Serine protease inhibitor Kazal type 1(SPINK1) downregulates E ‐cadherin and induces EMT of hepatoma cells to promote hepatocellular carcinoma metastasis via the MEK/ERK signaling pathway

ConclusionsBased on our results, SPINK1 might be an oncogene that induces EMT via the MEK/ERK pathway and a potential target for HCC therapy.

Source: Journal of Digestive Diseases - March 1, 2017 Category: Gastroenterology Authors: Ying Hai ‐Yan, Gong Chao‐Jie, Feng Yi, Jing Da‐Dao, Lun‐Gen Lu Tags: Original article Source Type: research