Differential expression of transcription factors NF- κB and STAT3 in periodontal ligament fibroblasts and gingiva of healthy and diseased individuals

Periodontal disease is a multifactorial disease which is initiated by microorganisms in dental plaque, but disease progression is predominantly mediated by host immnoinflammatory response which is dictated by genetic susceptibility and environmental factors (Kornman, 2008). Risk factors like diabetes mellitus, smoking etc can influence this host response. The exact molecular events happening in the host response are still not completely understood. Multiple cell signaling pathways and many intermediate factors take part in this inflammatory response.
Source: Archives of Oral Biology - Category: Dentistry Authors: Source Type: research