Glucomannan consumption elevates colonic alkaline phosphatase activity by up-regulating the expression of IAP-1, which is associated with increased production of protective factors for gut epithelial homeostasis in high-fat diet-fed rats

We previously reported that consumption of glucomannan-containing food (lily bulb) modulates gut microbiota and increases gut immunoglobulin A (IgA, index of intestinal immune function), mucins (index of intestinal barrier function), and colonic alkaline phosphatase (ALP) activity in rats fed a high-fat (HF) diet. Small intestinal ALP has an established protective effect in inflammatory diseases, whereas little is known about the function of colonic ALP activity. We hypothesized that dietary glucomannan would increase colonic ALP activity and the gene expression in rats fed a HF diet.

Source: Nutrition Research - May 19, 2017 Category: Nutrition Authors: Yukako Okazaki, Tetsuyuki Katayama Source Type: research