Editorial commentary: Importance of triglycerides

The relationship between low-density lipoprotein (LDL) cholesterol and cardiovascular disease (CVD) is clear both epidemiologically and genetically, from the clinical course of familial hypercholesterolemia. Moreover, the randomized controlled intervention trials in CVD prevention using statins [1] and most recently with evolocumab, a proprotein convertase subtilisin –kexin type 9 inhibitor [2] show a consistent and graded effect between LDL lowering and CVD event reduction. The same clear understanding is not present for the relationship between the plasma triglyceride concentration and disease.

Source: Trends in Cardiovascular Medicine - April 11, 2017 Category: Cardiology Authors: Alan F. Jones Source Type: research