Immunohistochemical expression of p53 and c-Myc at the invasive front of oral squamous cell carcinoma and its relation with clinicopathologic characteristics

The invasive tumor front (ITF) is the most progressed part of the tumor which consists of three to six tumor cell layers or detached tumor cell groups at the advancing edge of the oral squamous cell carcinoma (OSCC) [1]. It frequently shows a lower degree of differentiation and a higher grade of cellular dissociation in comparison with other parts of the tumor. It is believed that the integral prognostic information about the tumor's invasive and metastatic capacity can be deduced from ITF, where the deepest and presumably aggressive cells reside [2,3].
Source: Annals of Diagnostic Pathology - Category: Pathology Authors: Source Type: research