Muscle-specific and age-related changes in protein synthesis and protein degradation in response to hindlimb unloading in rats

In this study, we showed that age did not intensify the atrophy response to unloading in rats, but rather that the degree of atrophy was highly variable across muscles, indicating that changes in protein synthesis and protein degradation occur in a muscle-specific manner. Our data emphasize the importance of studying muscles of varying fiber-type and physiological function at multiple time points to fully understand the molecular mechanisms responsible for disuse atrophy.

Source: Journal of Applied Physiology - May 18, 2017 Category: Physiology Authors: Baehr, L. M., West, D. W. D., Marshall, A. G., Marcotte, G. R., Baar, K., Bodine, S. C. Tags: RESEARCH ARTICLE Source Type: research