DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential

Nature Reviews Molecular Cell Biology 18, 279 (2017). doi:10.1038/nrm.2017.3 Authors: Robert Hänsel-Hertsch, Marco Di Antonio & Shankar Balasubramanian Single-stranded guanine-rich DNA sequences can fold into four-stranded DNA structures called G-quadruplexes (G4s) that arise from the self-stacking of two or more guanine quartets. There has been considerable recent progress in the detection and mapping of G4 structures in the human genome and in biologically
Source: Nature Reviews Molecular Cell Biology - Category: Cytology Authors: Tags: Progress Source Type: research