Metabolic changes promote rejection of oncogenic cells

Nature Cell Biology 19, 414 (2017).
doi:10.1038/ncb3521

Authors: Jonathan L. Coloff & Joan S. Brugge
Dysfunctional cells are eliminated from epithelial monolayers by a process known as cell extrusion to maintain tissue homeostasis. Normal epithelial cells are now shown to induce the extrusion of oncogene-transformed cells by inducing metabolic changes in the oncogene-expressing cells through PDK4-mediated inhibition of PDH and mitochondrial metabolism.

Source: Nature Cell Biology - April 27, 2017 Category: Cytology Authors: Jonathan L. Coloff Joan S. Brugge Tags: News and Views Source Type: research