Terminating the replication helicase

Nature Cell Biology 19, 410 (2017). doi:10.1038/ncb3519 Authors: Vincent Gaggioli & Philip Zegerman A feature of the cell cycle is that the events of one cycle must be reset before the next one begins. A study now shows that the replication machinery is removed from fully replicated DNA by a conserved ubiquitin- and CDC48 (also known as p97)-dependent pathway. This explains how eukaryotic chromosomes are returned to the unreplicated state.

http://dx.doi.org/10.1038/ncb3519

Source: Nature Cell Biology - April 27, 2017 Category: Cytology Authors: Vincent Gaggioli Philip Zegerman Tags: News and Views Source Type: research

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