Progranulin, lysosomal regulation and neurodegenerative disease
Nature Reviews Neuroscience 18, 325 (2017).
doi:10.1038/nrn.2017.36
Authors: Aimee W. Kao, Andrew McKay, Param Priya Singh, Anne Brunet & Eric J. Huang
The discovery that heterozygous and homozygous mutations in the gene encoding progranulin are causally linked to frontotemporal dementia and lysosomal storage disease, respectively, reveals previously unrecognized roles of the progranulin protein in regulating lysosome biogenesis and function. Given the importance of lysosomes in cellular homeostasis,
Source: Nature Reviews Neuroscience - Category: Neuroscience Authors: Aimee W. Kao Andrew McKay Param Priya Singh Anne Brunet Eric J. Huang Tags: Progress Source Type: research