Progranulin, lysosomal regulation and neurodegenerative disease

Nature Reviews Neuroscience 18, 325 (2017). doi:10.1038/nrn.2017.36 Authors: Aimee W. Kao, Andrew McKay, Param Priya Singh, Anne Brunet & Eric J. Huang The discovery that heterozygous and homozygous mutations in the gene encoding progranulin are causally linked to frontotemporal dementia and lysosomal storage disease, respectively, reveals previously unrecognized roles of the progranulin protein in regulating lysosome biogenesis and function. Given the importance of lysosomes in cellular homeostasis,
Source: Nature Reviews Neuroscience - Category: Neuroscience Authors: Tags: Progress Source Type: research