Supplementation with Vitis vinifera L. skin extract improves insulin resistance and prevents hepatic lipid accumulation and steatosis in high-fat diet-fed mice

Non-alcoholic fatty liver disease is one of the most common complications of obesity. The Vitis vinifera L. grape skin extract (ACH09) is an important source of polyphenols, which are related to its antioxidant and antihyperglycemic activities. We hypothesized that ACH09 could also exert beneficial effects on metabolic disorders associated with obesity and evaluated ACH09 ’s influence on high-fat (HF) diet-induced hepatic steatosis and insulin resistance in C57BL/6 mice. The animals were fed a standard diet (10% fat, Control) or an HF diet (60% fat, HF) with or without ACH09 (200mg/kg-1d-1) for 12weeks.

Source: Nutrition Research - May 17, 2017 Category: Nutrition Authors: Izabelle Barcellos Santos, Graziele Freitas de Bem, Viviane Silva Cristino Cordeiro, Cristiane Aguiar da Costa, Lenize Costa Reis Marins de Carvalho, Ana Paula Machado da Rocha, Gisele Fran ça da Costa, Dayane Teixeira Ognibene, Roberto Soares de Moura, Source Type: research