Polyporus and Bupleuri radix effectively alter peripheral circadian clock phase acutely in male mice

In mammals, daily physiological events are precisely regulated by an internal circadian clock system. An important function of this system is to re-adjust the phase of the clock daily. In Japan, traditional herb medicines so-called crude drugs (Shoyaku) are widely used for many disease and some are reported to affect circadian clock impairment, suggesting some of them might have an ability to modify clock gene expression rhythms. Therefore, from selected 40 crude drugs, finding candidates that control the circadian clock phases was the first purpose of this study.

Source: Nutrition Research - May 17, 2017 Category: Nutrition Authors: Hiroaki Motohashi, Haruna Sukigara, Yu Tahara, Keisuke Saito, Mayu Yamazaki, Takuya Shiraishi, Yosuke Kikuchi, Atsushi Haraguchi, Shigenobu Shibata Source Type: research