Consumption of a liquid high-fat meal increases triglycerides but decreases high density lipoprotein cholesterol in abdominally-obese subjects with high postprandial insulin resistance

Abdominal obesity is associated with an increased risk of insulin resistance, which may be a potential contributor to dyslipidemia. However, the relationship between postprandial insulin resistance and lipid metabolism in abdominally-obese subjects remains unknown. We hypothesized that postprandial dyslipidemia would be exaggerated in abdominally-obese subjects with high postprandial insulin resistance. To test this hypothesis, serum glucose, insulin, triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and apolipoprotein B (Apo B) were measured at baseline and postprandial state at 0.5, 1, 2, 4, 6 and 8hours after a liquid high-fat meal in non-abdominally-obese controls (n=44) and abdominally-obese subjects with low (AO-LPIR, n=40), middle (AO-MPIR, n=40) and high postprandial insulin resistance (AO-HPIR, n=40) based on the tertiles ratio of the insulin to glucose areas under the curve.

Source: Nutrition Research - May 17, 2017 Category: Nutrition Authors: Feng Wang, Huixia Lu, Fukang Liu, Huizhen Cai, Hui Xia, Fei Guo, Yulan Xie, Guiling Huang, Miao Miao, Guofang Shu, Guiju Sun Source Type: research