In vivo phenotypic screening: clinical proof of concept for a drug repositioning approach

This article reviews examples of drugs identified by phenotypic observations and describes the use of the theraTRACE® in vivo screening platform for finding and developing new indications for discontinued clinical compounds. Clinical proof-of-concept for the platform is exemplified by MLR-1023, a repositioned compound that has recently shown significant clinical efficacy in Type 2 diabetes patients. These findings validate an in vivo screening approach for drug development and underscore the importance of alternatives to target and mechanism based strategies that have failed to produce adequate numbers of new medicines.
Source: Drug Discovery Today: Technologies - Category: Drugs & Pharmacology Source Type: research