Morphometric analysis of thalamic volume in progressive supranuclear palsy: in vivo evidence of regionally specific bilateral thalamic atrophy

We investigated whether differences were detectable in the volume and shape of the dorsal thalamus on magnetic resonance imaging in patients with progressive supranuclear palsy (PSP). Manual segmentation of the left and right thalami on magnetic resonance imaging scans occurred in 22 patients with clinically diagnosed PSP and 23 healthy controls; thalamic volumes (left, right, total) were calculated. Between group differences were explored by multivariate analysis of co-variance, using age and intracranial volume as covariates.
Source: Psychiatry Research: Neuroimaging - Category: Psychiatry Authors: Source Type: research