Geographical Difference of the Interaction of Sex With Treatment Strategy in Patients With Multivessel Disease and Left Main Disease: A Meta-Analysis From SYNTAX (Synergy Between PCI With Taxus and Cardiac Surgery), PRECOMBAT (Bypass Surgery Versus Angioplasty Using Sirolimus-Eluting Stent in Patients With Left Main Coronary Artery Disease), and BEST (Bypass Surgery and Everolimus-Eluting Stent Implantation in the Treatment of Patients With Multivessel Coronary Artery Disease) Randomized Controlled Trials [Coronary Artery Disease]

Conclusions— The present meta-analysis suggested the presence of the heterogeneous sex–treatment interaction across Asian and Western trials. Considering the ongoing globalization of our medical practice, the heterogeneity of the sex–treatment interaction needs to be well recognized and taken into account during the decision making of the treatment strategy. Clinical Trial Registrations— URL: https://www.clinicaltrials.gov. Unique identifiers: NCT00114972, NCT00997828, NCT00422968.

http://circinterventions.ahajournals.org/cgi/content/short/10/5/e005027?rss=1

Source: Circulation: Cardiovascular Interventions - May 11, 2017 Category: Cardiology Authors: Sotomi, Y., Onuma, Y., Cavalcante, R., Ahn, J.-M., Lee, C. W., van Klaveren, D., de Winter, R. J., Wykrzykowska, J. J., Farooq, V., Morice, M.-C., Steyerberg, E. W., Park, S.-J., Serruys, P. W. Tags: Cardiovascular Surgery, Percutaneous Coronary Intervention, Revascularization Coronary Artery Disease Source Type: research