MicroRNA-driven deregulation of cytokine expression helps development of drug resistance in metastatic melanoma

microRNAs (miRNAs) are short regulatory RNAs of 19 –24 long nucleotides generated by a complex and tightly regulated biogenesis process, constituting the most expressed class of non-coding RNAs in eukaryotic cells, whose main function is the post-transcriptional modulation of gene expression [1,2]. miRNAs are able to affect mRNAs through a perfect or near-perfect binding to their 3′UTR, causing mRNA degradation or block of translation, respectively (Fig. 1A) [3]. In particular, the “seed region” of each miRNA, which is the portion on its 5′end (from position 2 to 8), is responsible for recognizing the target mRNAs [4].
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Short survey Source Type: research