Resolution of glucose intolerance in long-term high-fat, high-sucrose-fed mice

In conclusion, we have made the paradoxical observation that long-term HFSD feeding results in the resolution of glucose intolerance in the C57Bl/6 mouse. Mechanistically, we propose that the gross expansion of subcutaneous adipose tissue increases the glucose disposal capacity of the HFSD-fed mouse, which overcomes the prevailing insulin resistance to improve glucose tolerance.

Source: Journal of Endocrinology - May 15, 2017 Category: Endocrinology Authors: Kowalski, G. M., Kraakman, M. J., Mason, S. A., Murphy, A. J., Bruce, C. R. Tags: Research Source Type: research