Dissociation of Local and Global Skeletal Muscle Oxygen Transport Metrics in Type 2 Diabetes

Exercise capacity is impaired in type 2 diabetes, and this impairment predicts excess morbidity and mortality. This defect appears to involve excess skeletal muscle deoxygenation, but the underlying mechanisms remain unclear. We hypothesized that reduced blood flow, reduced local recruitment of blood volume/hematocrit, or both contribute to excess skeletal muscle deoxygenation in type 2 diabetes.

Source: Journal of Diabetes and Its Complications - May 14, 2017 Category: Endocrinology Authors: P. Mason McClatchey, Timothy A. Bauer, Judith G. Regensteiner, Irene E. Schauer, Amy G. Huebschmann, Jane E.B. Reusch Source Type: research