Insulin signaling in various equine tissues under basal conditions and acute stimulation by intravenously-injected insulin

The aim of the study was to analyze key proteins of the equine insulin signaling cascade and their extent of phosphorylation in biopsies from muscle tissue (MT), liver tissue (LT), and nuchal (NUAT), subcutaneous (SCAT) and retroperitoneal adipose tissues (RPAT). This was investigated under unstimulated (B1) and intravenously insulin stimulated (B2) conditions, which were achieved by injection of insulin (0.1 IU/kg bodyweight (BW)) and glucose (150 mg/kg BW). Twelve warmblood horses aged 15 ± 6.8 years (yr), weighing 559 ± 79 kg and with a mean body condition score of 4.7 ± 1.5 were included in the study.
Source: Domestic Animal Endocrinology - Category: Endocrinology Authors: Source Type: research