Electrical Substrate Elimination in 135 Consecutive Patients With Brugada Syndrome [Original Articles]

Conclusions— In Brugada syndrome, AES is commonly located in the right ventricle epicardium and ajmaline exposes its extent and distribution, which is correlated with the degree of coved ST-elevation. AES elimination by radiofrequency ablation results in ECG normalization and VT/VF noninducibility. Substrate-based ablation is effective in potentially eliminating the arrhythmic consequences of this genetic disease. Clinical Trial Registration— URL: https://clinicaltrials.gov. Unique identifier: NCT02641431.

http://circep.ahajournals.org/cgi/content/short/10/5/e005053?rss=1

Source: Circulation: Arrhythmia and Electrophysiology - May 12, 2017 Category: Cardiology Authors: Pappone, C., Brugada, J., Vicedomini, G., Ciconte, G., Manguso, F., Saviano, M., Vitale, R., Cuko, A., Giannelli, L., Calovic, Z., Conti, M., Pozzi, P., Natalizia, A., Crisa, S., Borrelli, V., Brugada, R., Sarquella-Brugada, G., Guazzi, M., Frigiola, A., Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Sudden Cardiac Death, Ventricular Fibrillation Original Articles Source Type: research