TGF-{beta}1 (Transforming Growth Factor-{beta}1) Plays a Pivotal Role in Cardiac Myofibroblast Arrhythmogenicity [Original Articles]

Conclusions—
TGF-β1 profoundly alters the electrophysiological phenotype of cardiac myofibroblasts. Apart from possibly contributing to the control of cell function in general, the changes proved to be pivotal for proarrhythmic myofibroblast–cardiomyocyte crosstalk in vitro, which suggests that TGF-β1 may play a potentially important role in arrhythmogenesis of the fibrotic heart.

Source: Circulation: Arrhythmia and Electrophysiology - May 12, 2017 Category: Cardiology Authors: Salvarani, N., Maguy, A., De Simone, S. A., Miragoli, M., Jousset, F., Rohr, S. Tags: Arrhythmias, Basic Science Research, Fibrosis, Growth Factors/Cytokines, Ion Channels/Membrane Transport Original Articles Source Type: research