Inhibitors of soluble epoxide hydrolase minimize ischemia ‐reperfusion‐induced cardiac damage in normal, hypertensive, and diabetic rats

ConclusionsProphylactic treatment with sEH inhibitors decreased myocardial damage due to IR, hypertension and diabetes, and decreased endothelial dysfunction created by diabetes and hypertension. Therefore, inhibitors of sEH are useful probes to study cardiovascular pathology, and inhibition of the sEH is a potential approach in the management of IR‐induced cardiac damage and endothelial dysfunction‐related cardiovascular disorders.

Source: Cardiovascular Therapeutics - May 12, 2017 Category: Cardiology Authors: Oliul Islam, Prashanth Patil, Sumanta K. Goswami, Rema Razdan, Mohammed N. Inamdar, Mohammed Rizwan, Jubin Mathew, Bora Inceoglu, Kin S. Stephen Lee, Sung H. Hwang, Bruce D. Hammock Tags: ORIGINAL RESEARCH ARTICLE Source Type: research