Aortopathy in a Mouse Model of Marfan Syndrome Is Not Mediated by Altered Transforming Growth Factor {beta} Signaling [Vascular Medicine]

ConclusionsIn young Fbn1C1039G/+ mice, aortopathy develops in the absence of detectable alterations in SMC TGF‐β signaling. Loss of physiologic SMC TGF‐β signaling exacerbates MFS‐associated aortopathy. Our data support a protective role for SMC TGF‐β signaling during early development of MFS‐associated aortopathy.

Source: JAHA:Journal of the American Heart Association - January 24, 2017 Category: Cardiology Authors: Wei, H., Hu, J. H., Angelov, S. N., Fox, K., Yan, J., Enstrom, R., Smith, A., Dichek, D. A. Tags: Animal Models of Human Disease, Growth Factors/Cytokines, Genetically Altered and Transgenic Models, Aneurysm, Vascular Disease Original Research Source Type: research