High-Saturated-Fat Diet Increases Circulating Angiotensin-Converting Enzyme, Which Is Enhanced by the rs4343 Polymorphism Defining Persons at Risk of Nutrient-Dependent Increases of Blood Pressure [Hypertension]

ConclusionsThe HF‐diet‐induced increase of ACE serum concentrations reveals ACE to be a potential molecular link between dietary fat intake and hypertension and cardiovascular disease (CVD). The GG genotype of the ACE rs4343 polymorphism represents a robust nutrigenetic marker for an unfavorable response to high‐saturated‐fat diets.Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01631123.

Source: JAHA:Journal of the American Heart Association - January 17, 2017 Category: Cardiology Authors: Schuler, R., Osterhoff, M. A., Frahnow, T., Seltmann, A.–C., Busȷahn, A., Kabisch, S., Xu, L., Mosig, A. S., Spranger, J., Mohlig, M., Hornemann, S., Kruse, M., Pfeiffer, A. F. H. Tags: ACE/Angiotensin Receptors/Renin Angiotensin System, Clinical Studies, Diet and Nutrition, Genetic, Association Studies, High Blood Pressure Original Research Source Type: research