Females Are Protected From Iron-Overload Cardiomyopathy Independent of Iron Metabolism: Key Role of Oxidative Stress [Heart Failure]

ConclusionsMale and female mice respond differently to iron‐overload‐mediated effects on heart structure and function, and females are markedly protected from iron‐overload cardiomyopathy. Ovariectomy in female mice exacerbated iron‐induced myocardial injury and precipitated severe cardiac dysfunction during iron‐overload conditions, whereas 17β‐estradiol therapy was protective in male iron‐overloaded mice.

Source: JAHA:Journal of the American Heart Association - January 23, 2017 Category: Cardiology Authors: Das, S. K., Patel, V. B., Basu, R., Wang, W., DesAulniers, J., Kassiri, Z., Oudit, G. Y. Tags: Oxidant Stress, Pathophysiology, Cardiomyopathy, Heart Failure Original Research Source Type: research