Cardiac Overexpression of S100A6 Attenuates Cardiomyocyte Apoptosis and Reduces Infarct Size After Myocardial Ischemia-Reperfusion [Coronary Heart Disease]

ConclusionsS100A6 overexpression by ultrasound‐targeted microbubble destruction helps ameliorate myocardial ischemia‐reperfusion, resulting in lower mortality and improved left ventricular systolic function post–ischemia‐reperfusion via attenuation of apoptosis, reduction in cardiac hypertrophy, and reduced infarct size. Our results indicate that S100A6 is a potential therapeutic target for acute myocardial infarction.

Source: JAHA:Journal of the American Heart Association - February 7, 2017 Category: Cardiology Authors: Mofid, A., Newman, N. S., Lee, P. J. H., Abbasi, C., Matkar, P. N., Rudenko, D., Kuliszewski, M. A., Chen, H. H., Afrasiabi, K., Tsoporis, J. N., Gramolini, A. O., Connelly, K. A., Parker, T. G., Leong-Poi, H. Tags: Calcium Cycling/Excitation-Contraction Coupling, Gene Therapy, Ischemia, Hypertrophy, Myocardial Infarction Original Research Source Type: research