Serum N1-Methylnicotinamide is Associated With Coronary Artery Disease in Chinese Patients [Coronary Heart Disease]

BackgroundWe previously reported that serum N1‐methylnicotinamide (me‐Nam), an indicator of nicotinamide N‐methyltransferase activity, is associated with obesity and diabetes mellitus in Chinese patients. However, whether nicotinamide N‐methyltransferase plays a role in human coronary artery disease (CAD) remains to be elucidated. We aim to investigate the associations of serum me‐Nam with CAD in Chinese patients.Methods and ResultsSerum me‐NAM was measured by liquid chromatography‐mass spectrometry in patients with (n=230) or without (n=103) CAD as defined by coronary angiography. The severity of CAD was expressed by number of diseased coronary arteries. Serum me‐Nam was higher (7.65 ng/mL versus 4.95 ng/mL, P

Source: JAHA:Journal of the American Heart Association - February 7, 2017 Category: Cardiology Authors: Liu, M., Chu, J., Gu, Y., Shi, H., Zhang, R., Wang, L., Chen, J., Shen, L., Yu, P., Chen, X., Ju, W., Wang, Z. Tags: Inflammation, Coronary Artery Disease Original Research Source Type: research