Isosorbide Dinitrate, With or Without Hydralazine, Does Not Reduce Wave Reflections, Left Ventricular Hypertrophy, or Myocardial Fibrosis in Patients With Heart Failure With Preserved Ejection Fraction [Heart Failure]

ConclusionsISDN, with or without hydralazine, does not exert beneficial effects on RM, left ventricular remodeling, or submaximal exercise and is poorly tolerated. ISDN+hydral appears to have deleterious effects on RM, myocardial remodeling, and submaximal exercise. Our findings do not support the routine use of these vasodilators in patients with heart failure with preserved ejection fraction.Clinical Trial RegistrationURL: www.clinicaltrials.gov. Unique identifier: NCT01516346.

Source: JAHA:Journal of the American Heart Association - February 20, 2017 Category: Cardiology Authors: Zamani, P., Akers, S., Soto-Calderon, H., Beraun, M., Koppula, M. R., Varakantam, S., Rawat, D., Shiva-Kumar, P., Haines, P. G., Chittams, J., Townsend, R. R., Witschey, W. R., Segers, P., Chirinos, J. A. Tags: Heart Failure, Remodeling Original Research Source Type: research