Tissue Transglutaminase Modulates Vascular Stiffness and Function Through Crosslinking-Dependent and Crosslinking-Independent Functions [Vascular Medicine]

ConclusionsTG2 modulates vascular function/tone by altering SMC contractility independent of its crosslinking function and contributes to vascular stiffness by regulating SMC proliferation and matrix remodeling.

Source: JAHA:Journal of the American Heart Association - February 3, 2017 Category: Cardiology Authors: Steppan, J., Bergman, Y., Viegas, K., Armstrong, D., Tan, S., Wang, H., Melucci, S., Hori, D., Park, S. Y., Barreto, S. F., Isak, A., Jandu, S., Flavahan, N., Butlin, M., An, S. S., Avolio, A., Berkowitz, D. E., Halushka, M. K., Santhanam, L. Tags: Animal Models of Human Disease, Cell Biology/Structural Biology, Vascular Biology Original Research Source Type: research