Two Decades of Cardiovascular Trials With Primary Surrogate Endpoints: 1990-2011 [Health Services and Outcomes Research]

ConclusionsAlthough cardiovascular surrogate outcomes trials frequently show superiority of the tested intervention, they are infrequently followed by a prominent outcomes trial. When there was a high‐profile clinical outcomes study, nearly half of the positive surrogate trials were not validated. Cardiovascular surrogate outcome trials may be more appropriate for excluding benefit from the patient perspective than for identifying it.

Source: JAHA:Journal of the American Heart Association - March 21, 2017 Category: Cardiology Authors: Bikdeli, B., Punnanithinont, N., Akram, Y., Lee, I., Desai, N. R., Ross, J. S., Krumholz, H. M. Tags: Quality and Outcomes Original Research Source Type: research