Metabolic Mediators of the Effects of Family History and Genetic Risk Score on Coronary Heart Disease—Findings From the Malmo Diet and Cancer Study [Coronary Heart Disease]

ConclusionsA fraction of the CHD risk associated with family history or with GRS50 is mediated through elevated blood lipids and hypertension, but not through diabetes mellitus. However, a major part (≥80%) of the genetic effect operates independently of established metabolic risk factor pathways.

Source: JAHA:Journal of the American Heart Association - March 20, 2017 Category: Cardiology Authors: Fritz, J., Shiffman, D., Melander, O., Tada, H., Ulmer, H. Tags: Epidemiology, Risk Factors, Genetics, Coronary Artery Disease Original Research Source Type: research