Altered MicroRNA Expression Is Responsible for the Pro-Osteogenic Phenotype of Interstitial Cells in Calcified Human Aortic Valves [Valvular Heart Disease]

ConclusionsIn AVICs of calcified valves, increased levels of miR‐486 induce myofibroblastic transition to upregulate Runx2 and Osx expression and synergize with miR‐204 deficiency to elevate cellular and valvular pro‐osteogenic activity. These novel findings indicate that modulation of the epigenetic mechanism underlying valvular pro‐osteogenic activity has therapeutic potential for prevention of calcific aortic valve disease progression.

Source: JAHA:Journal of the American Heart Association - April 24, 2017 Category: Cardiology Authors: Song, R., Fullerton, D. A., Ao, L., Zhao, K.-s., Reece, T. B., Cleveland, J. C., Meng, X. Tags: Cell Biology/Structural Biology, Cell Signaling/Signal Transduction, Vascular Biology, Gene Expression & Regulation, Valvular Heart Disease Original Research Source Type: research