Circulating MicroRNAs in Delayed Cerebral Infarction After Aneurysmal Subarachnoid Hemorrhage [Cardiovascular Surgery]

BackgroundDelayed cerebral infarction (DCI) is a major cause of morbidities after aneurysmal subarachnoid hemorrhage (SAH) and typically starts at day 4 to 7 after initial hemorrhage. MicroRNAs (miRNAs) play an important role in posttranscriptional gene expression control, and distinctive patterns of circulating miRNA changes have been identified for some diseases. We aimed to investigate miRNAs that characterize SAH patients with DCI compared with those without DCI.Methods and ResultsCirculating miRNAs were collected on day 7 after SAH in healthy, SAH‐free controls (n=20), SAH patients with DCI (n=20), and SAH patients without DCI (n=20). We used the LASSO (least absolute shrinkage and selection operator) method of regression analysis to characterize miRNAs associated with SAH patients with DCI compared with those without DCI. In the 28 dysregulated miRNAs associated with DCI and SAH, we found that a combination of 4 miRNAs (miR‐4532, miR‐4463, miR‐1290, and miR‐4793) could differentiate SAH patients with DCI from those without DCI with an area under the curve of 100% (95% CI 1.000–1.000, P

Source: JAHA:Journal of the American Heart Association - April 25, 2017 Category: Cardiology Authors: Lu, G., Wong, M. S., Xiong, M. Z. Q., Leung, C. K., Su, X. W., Zhou, J. Y., Poon, W. S., Zheng, V. Z. Y., Chan, W. Y., Wong, G. K. C. Tags: Intracranial Hemorrhage Original Research Source Type: research