An NPPB Promoter Polymorphism Associated With Elevated N-Terminal pro-B-Type Natriuretic Peptide and Lower Blood Pressure, Hypertension, and Mortality [Genetics]

ConclusionsThe rs198389 G allele in the NPPB promoter is associated with elevated levels of NT‐proBNP throughout adult life, reduced blood pressure, hypertension and cardiovascular mortality, and increased lifespan.

Source: JAHA:Journal of the American Heart Association - March 24, 2017 Category: Cardiology Authors: Seidelmann, S. B., Vardeny, O., Claggett, B., Yu, B., Shah, A. M., Ballantyne, C. M., Selvin, E., MacRae, C. A., Boerwinkle, E., Solomon, S. D. Tags: Risk Factors, Genetic, Association Studies, Hypertension, Blood Pressure, Mortality/Survival Original Research Source Type: research