Monocrotaline Induces Endothelial Inȷury and Pulmonary Hypertension by Targeting the Extracellular Calcium-Sensing Receptor [Hypertension]

ConclusionsMonocrotaline aggregates on and activates the CaSR of pulmonary artery endothelial cells to trigger endothelial damage and, ultimately, induces pulmonary hypertension.

Source: JAHA:Journal of the American Heart Association - March 22, 2017 Category: Cardiology Authors: Xiao, R., Su, Y., Feng, T., Sun, M., Liu, B., Zhang, J., Lu, Y., Li, J., Wang, T., Zhu, L., Hu, Q. Tags: Animal Models of Human Disease, Basic Science Research, Cell Signaling/Signal Transduction, Vascular Biology Original Research Source Type: research