{beta}-Adrenergic Stimulation Induces Histone Deacetylase 5 (HDAC5) Nuclear Accumulation in Cardiomyocytes by B55{alpha}-PP2A-Mediated Dephosphorylation [Molecular Cardiology]

Conclusionsβ‐AR stimulation induces HDAC5 nuclear accumulation in cardiomyocytes by a mechanism that is protein kinase A‐dependent but requires B55α‐PP2A‐mediated dephosphorylation of Ser259/Ser498 rather than protein kinase A‐mediated phosphorylation of Ser279.

Source: JAHA:Journal of the American Heart Association - March 25, 2017 Category: Cardiology Authors: Weeks, K. L., Ranieri, A., Karaś, A., Bernardo, B. C., Ashcroft, A. S., Molenaar, C., McMullen, J. R., Avkiran, M. Tags: Basic Science Research, Cell Signaling/Signal Transduction, Mechanisms, Myocardial Biology, Hypertrophy Original Research Source Type: research