Synthesis, radiolabeling and preclinical evaluation of a [11C]GMOM derivative as PET radiotracer for the ion channel of the N-methyl-D-aspartate receptor

Presently available PET ligands for the NMDAr ion channel generally suffer from fast metabolism. The purpose of this study was to develop a metabolically more stable ligand for the NMDAr ion channel, taking [11C]GMOM ([11C]1) as the lead compound.

Source: Nuclear Medicine and Biology - May 8, 2017 Category: Nuclear Medicine Authors: Pieter J Klein, Robert C Schuit, Athanasios Metaxas, Johannes AM Christiaans, Esther Kooijman, Adriaan A Lammertsma, Bart NM van Berckel, Albert D Windhorst Source Type: research