Systematic substitutions at BLIP position 50 result in changes in binding specificity for class A β-lactamases

The production of β-lactamases by bacteria is the most common mechanism of resistance to the widely prescribed β-lactam antibiotics. β-lactamase inhibitory protein (BLIP) competitively inhibits class A β-lacta...

Source: BMC Biochemistry - March 6, 2017 Category: Biochemistry Authors: Carolyn J. Adamski and Timothy Palzkill Source Type: research