Preclinical transgenic and patient ‐derived xenograft models recapitulate the radiological features of human adamantinomatous craniopharyngioma

Conclusions: The Hesx1Cre/+;Ctnnb1l°x(ex3)/+ transgenic mouse model and cerebral patient‐derived ACP xenografts recapitulate a number of the key radiological features of the human disease and provide promising foundations for in vivo trials of novel therapeutics for the treatment of these tumours. This article is protected by copyright. All rights reserved.

Source: Brain Pathology - May 1, 2017 Category: Neurology Authors: Jessica K. R. Boult, John R. Apps, Annett H ölsken, J. Ciaran Hutchinson, Gabriela Carreno, Laura S. Danielson, Laura M. Smith, Tobias Bäuerle, Rolf Buslei, Michael Buchfelder, Alex K. Virasami, Alexander Koers, Owen J. Arthurs, Thomas S. Jacques, Louis Tags: Research Article Source Type: research