Daidzein stimulates osteogenesis facilitating proliferation, differentiation and anti-apoptosis in human osteoblast-like MG-63 cells via ER-dependent MEK/ERK and PI3K/Akt activation

Daidzein, a natural soy isoflavone, has a structure similar to estradiol and exhibiting bone-sparing effects against osteoporosis. However, the molecular mechanisms of osteogenesis remain unclear. We hypothesized that daidzein stimulates osteogenesis through estrogen receptor (ER)-dependent signal pathways. To test this hypothesis, we investigated the effects of daidzein compared with 17 β-estradiol (E2) on proliferation, differentiation and cisplatin-induced apoptosis in human osteoblast-like MG-63 cells containing two ER isoforms.
Source: Nutrition Research - Category: Nutrition Authors: Source Type: research