SNX27 interactome in T lymphocytes identifies ZO ‐2 dynamic redistribution at the immune synapse

This study broadens our knowledge of SNX27 function in T lymphocytes, and suggests that pathways that delimit polarized structures in nervous and epithelial systems also participate in IS regulation. Graphical abstract The role of sorting nexin 27 (SNX27) in the recycling of PDZ‐interacting neuronal proteins has been widely studied. In T lymphocytes, SNX27 localizes to the immune synapse (IS) where its function remains poorly understood. Using a proteomic strategy, we identified SNX27 PDZ‐dependent and independent interactome in IS‐forming T cells. We showed that SNX27 participates in the dynamics of zona occludens‐2 (ZO‐2) at the IS, which was not previously reported as an IS component.
Source: Traffic - Category: Research Authors: Tags: ORIGINAL ARTICLE Source Type: research