Probabilistic pharmacokinetic models of decompression sickness in humans, part 1: Coupled perfusion-limited compartments

Decompression sickness (DCS) is a disease caused by gas bubbles forming in body tissues following a reduction in ambient pressure, such as occurs in scuba diving. Probabilistic models for quantifying the risk of DCS are typically composed of a collection of independent, perfusion-limited theoretical tissue compartments which describe gas content or bubble volume within these compartments. It has been previously shown that ‘pharmacokinetic’ gas content models, with compartments coupled in series, show promise as predictors of the incidence of DCS.
Source: Computers in Biology and Medicine - Category: Bioinformatics Authors: Source Type: research