Contractile abnormalities of mouse muscles expressing hyperkalemic periodic paralysis mutant NaV1.4 channels do not correlate with Na+ influx or channel content

This study provides evidence that HyperKPP phenotype does not depend solely on the NaV1.4 content or Na+ influx and that the diaphragm does not depend solely on Na+-K+ pumps to ameliorate the phenotype.

Source: Physiological Genomics - June 1, 2014 Category: Genetics & Stem Cells Authors: Lucas, B., Ammar, T., Khogali, S., DeJong, D., Barbalinardo, M., Nishi, C., Hayward, L. J., Renaud, J.-M. Tags: General Interest Source Type: research