The influence of rosuvastatin on the gastrointestinal microbiota and host gene expression profiles

This study suggests that a commonly used statin (RSV) leads to an altered gut microbial composition in normal mice with attendant impacts on local gene expression profiles, a finding that should prompt further studies to investigate the implications of statins for gut microbiota stability and health in humans.
NEW & NOTEWORTHY This work demonstrates that rosuvastatin administration in mice affects the gastrointestinal microbiota, influences bile acid metabolism, and alters transcription of genes encoding factors involved in gut homeostasis and immunity in the gastrointestinal tract.

Source: AJP: Gastrointestinal and Liver Physiology - May 4, 2017 Category: Gastroenterology Authors: Nolan, J. A., Skuse, P., Govindarajan, K., Patterson, E., Konstantinidou, N., Casey, P. G., MacSharry, J., Shanahan, F., Stanton, C., Hill, C., Cotter, P. D., Joyce, S. A., Gahan, C. G. M. Tags: RESEARCH ARTICLE Source Type: research