Deoxyribonuclease partially ameliorates thioacetamide-induced hepatorenal injury

In conclusion, the study confirmed the hepatotoxic and nephrotoxic effect of thioacetamide. The associated increase in cell-free DNA seems to be involved in hepatorenal pathogenesis because treatment with deoxyribonuclease resulted in a partial prevention of hepatorenal injury. Further experiments will focus on the effects of long-term treatment with deoxyribonuclease in other clinically more relevant models. Clinical studies should test endogenous deoxyribonuclease activity as a potential risk determinant for kidney or liver failure. NEW & NOTEWORTHY Thioacetamide-induced hepatorenal injury resulted in higher plasma cell-free DNA. Deoxyribonuclease decreased average cell-free DNA of mitochondrial origin but not nuclear origin. Deoxyribonuclease partially prevented hepatorenal injury in rats.

http://ajpgi.physiology.org/cgi/content/abstract/312/5/G457?rss=1

Source: AJP: Gastrointestinal and Liver Physiology - May 4, 2017 Category: Gastroenterology Authors: Vokalova, L., Laukova, L., Conka, J., Meliskova, V., Borbelyova, V., Babickova, J., Tothova, L., Hodosy, J., Vlkova, B., Celec, P. Tags: RESEARCH ARTICLE Source Type: research