MicroRNA-29a mediates the impairment of intestinal epithelial integrity induced by intrauterine growth restriction in pig

In conclusion, this study reveals that IUGR-impaired intestinal barrier function is associated with downregulated ECM and TJ protein expression mediated by the upregulation of miR-29a. NEW & NOTEWORTHY Intrauterine growth restricted (IUGR) remains a major problem for both human health and animal production due to its association with high rates of preweaning morbidity and mortality. We have identified the abnormal expression of microRNA-29a (miR-29a) in the small intestine of IUGR neonates, as well as its targets and mechanisms. These results provide new information about biological characteristics of IUGR-affected intestinal dysfunction and can lead to the development of potentially solution for preventing and treating IUGR in the future.

http://ajpgi.physiology.org/cgi/content/abstract/312/5/G434?rss=1

Source: AJP: Gastrointestinal and Liver Physiology - May 4, 2017 Category: Gastroenterology Authors: Zhu, Y., Wang, W., Yuan, T., Fu, L., Zhou, L., Lin, G., Zhao, S., Zhou, H., Wu, G., Wang, J. Tags: RESEARCH ARTICLE Source Type: research