Metabolic regulation of suppressive myeloid cells in cancer

Malignant transformation of cells leads to enhanced glucose uptake and the conversion of a larger fraction of pyruvate into lactate, even under normoxic conditions (aerobic glycolysis). This phenomenon is known as the Warburg effect and serves to generate biosynthetic precursors, thus facilitating the survival of rapidly proliferating malignant cells.
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Mini review Source Type: research