Assessing the impact of FoxP3 and Vav1 gene polymorphisms on kidney allograft survival
FoxP3 and Vav1 are known to be involved in the development of regulatory T cells. Two polymorphic sites in the FoxP3 promoter (rs3761548 and a (GT)
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‐dinucleotide repeat) and 2 single nucleotide polymorphisms in intron 1 of the Vav1 gene (rs2546133 and rs2617822) have been shown to correlate with gene expression levels. We investigated a potential impact of FoxP3 and Vav1 genetic variants on kidney allograft failure using samples and data of the Collaborative Transplant Study. A cohort of 384 kidney transplant patients was tested. We found no significant association of FoxP3 promoter rs3761548 or (GT)
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repeat length with presumed immunological graft failure. The genotype frequencies of Vav1 intron polymorphisms did not significantly differ between patients with graft failure and matched controls.
Source: Tissue Antigens - Category: Allergy & Immunology Authors: M. Adamek, B. D öhler, K. K. Hasan, G. Fiedler, S. Scherer, G. Opelz, T. H. Tran Tags: BRIEF COMMUNICATION Source Type: research
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