An endocannabinoid mechanism promoting resilience to traumatic stress

Stress is a major risk factor for the development of affective disorders including major depression and posttraumatic stress disorder, and relapse to alcohol use during abstinence. Understanding the neurobiological mechanisms conferring resilience to the adverse consequences of stress could have broad implications for the treatment of anxiety disorders and alcohol use disorders. We utilized inter-individual differences in stress-susceptibility to demonstrate a critical role for the endogenous cannabinoid 2-arachidonoylglycerol (2-AG) in stress-resilience.

Source: Alcohol - May 1, 2017 Category: Addiction Authors: Rebecca J. Bluett, Rita B áldi, Andre Haymer, Nolan D. Hartley, Andrew Gaulden, David Marcus, Ramzi Mardam-Bey, Brian C. Shonesy, Jashim Uddin, Lawrence J. Marnett, Roger J. Colbran, Danny G. Winder, Sachin Patel Tags: Symposia Source Type: research